Katalay.net

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

0 402

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

Male contraceptive compound stops sperm without affecting hormones: Study in monkeys
In preclinical tests, researchers have shown how a new compound can immobilize sperm temporarily without side effects.

A new study published today in the journal PLOS ONE details how a compound called EP055 binds to sperm proteins to significantly slow the overall mobility of the sperm without affecting hormones, making EP055 a potential "male pill" without side effects.

"Simply put, the compound turns-off the sperm's ability to swim, significantly limiting fertilization capabilities," said lead investigator Michael O'Rand, PhD, retired professor of cell biology and physiology in the University of North Carolina at Chapel Hill School of Medicine, and president/CEO of Eppin Pharma, Inc. "This makes EP055 an ideal candidate for non-hormonal male contraception."

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

Currently, condoms and surgical vasectomy are the only safe forms of birth control currently available for men. There are hormonal drugs in clinical trials that target the production of sperm, but these affect the natural hormones in men much like female contraceptives affect hormones in women.

During the study, thirty hours following a high-dose intravenous infusion of EP055 in male rhesus macaques, O'Rand and researchers in the Oregon National Primate Research Center at OHSU in Portland, Oregon, found no indication of normal sperm motility. Further, no physical side effects were observed.

Male Contraceptive Compound Stops Sperm Without Affecting Hormones

"At 18 days post-infusion, all macaques showed signs of complete recovery, suggesting that the EP055 compound is indeed reversible," said study co-investigator Mary Zelinski, PhD, research associate professor at the ONPRC at OHSU and associate professor of obstetrics and gynecology in the OHSU School of Medicine.

O'Rand and Zelinski indicate that more work is needed before EP055 becomes available for human use. They and their teams have begun to test a pill form of the compound and will eventually conduct a mating trial of EP055's effectiveness against pregnancy.

Write a Review

Facebook Comments

Booking.com

Recent Posts

7 Foods That Feed Your Thyroid7 Foods That Feed Your Thyroid

photo by Traditional Cooking SchoolIncrease? Do you fee...

0 131
Fasting Increases Metabolism And Fights AgingFasting Increases Metabolism And Fights Aging

The latest study examining the effects of fasting on th...

0 124
What Is Periodontal Disease? Symptoms, Causes And TreatmentWhat Is Periodontal Disease? Symptoms, Causes And Treatment

We pay special attention to the other aspects of our bo...

0 162

Most Read

Common Drug May Increase Lung Cancer RiskCommon Drug May Increase Lung Cancer Risk

A study published this week in The BMJ concludes that t...

0 1.303
What Can Cause Joint Pains In Children?What Can Cause Joint Pains In Children?

When a child complains of joint or leg pains, parents o...

0 1.211
Common Drugs Lead To Millions Of Cases Of Lung DiseaseCommon Drugs Lead To Millions Of Cases Of Lung Disease

Common drugs that doctors prescribe to treat heart prob...

0 1.015

Popular Posts

Are Probiotics Good or Bad for Crohn's Disease?Are Probiotics Good or Bad for Crohn's Disease?

Probiotics are living microorganisms, including bacteri...

0 744
What You Need To Know About LymphomaWhat You Need To Know About Lymphoma

Lymphoma is a cancer of the lymphatic system. It affect...

0 657
Metastatic Prostate Cancer: What You Need To KnowMetastatic Prostate Cancer: What You Need To Know

Prostate cancer occurs when the cells in the prostate b...

0 618

Donate

Tags